Highly cited research from the core

Many discoveries have relied upon careful measurement of body composition and metabolic rates in un-anesthetized, freely moving mice. One metric to determine the impact of a scientific publication is how many times other scientific articles have referred to that work–or citations.

Selected highly cited publications (>100 citations) utilizing one or more of the facilities at the BIDMC are listed below:

Mice lacking melanin-concentrating hormone are hypophagic and lean Shimada et al Nature 1998
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice Klaman et al MCB 2000
βAR signaling required for diet-induced thermogenesis and obesity resistance Bachman et al Science 2002
Melanin-concentrating Hormone Is a Critical Mediator of the Leptin-Deficient Phenotype Segal-Lieberman et al PNAS 2003
Mice lacking ghrelin receptors resist the development of diet-induced obesity Zigman et al JCI 2005
Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity Kershaw et al Diabetes 2005
Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms Kokkotou et al AJP 2005
TLR4 links innate immunity and fatty acid–induced insulin resistance Shi et al JCI 2006
Neuronal PTP1B regulates body weight, adiposity and leptin action Bence et al Nature Medicine 2006
A high-fat, ketogenic diet induces a unique metabolic state in mice Kennedy et al AJP 2007
Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice Bradley et al AJP 2008
Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle Martin et al JBC 2008
Selective Inactivation of Socs3 in SF1 Neurons Improves Glucose Homeostasis without Affecting Body Weight Zhang et al Endocrinology 2008
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis, Badman et al 2009 Endocrinology
Leptin-dependent control of glucose balance and locomotor activity by POMC neurons Huo et al Cell Metabolism 2009
Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis Preitner et al AJP 2009
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice Krashes et al JCI 2011
Transcriptional control of adipose lipid handling by IRF4 Eguchi et al Cell Metabolism 2011
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons Vong et al Neuron 2011
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis Fisher et al Genes and Development 2012
Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone Liu et al Neuron 2012
IRF4 is a key thermogenic transcriptional partner of PGC-1α Kong et al Cell 2014
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity Kraus et al Nature 2014
An Erk/Cdk5 axis controls the diabetogenic actions of PPARγ Banks et al Nature 2015
Central fibroblast growth factor 21 browns white fat via sympathetic action in male mice Douris et al Endocrinology 2015
PTH/PTHrP receptor mediates cachexia in models of kidney failure and cancer Kir et al Cell Metabolism 2016
Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity Kazak et al Cell Metabolism 2017

Funding: the Energy balance core is sponsored by the BIDMC Department of Medicine and the Harvard Digestive Disease Centers

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