Highly cited research from the core

Many discoveries have relied upon careful measurement of body composition and metabolic rates in un-anesthetized, freely moving mice. One metric to determine the impact of a scientific publication is how many times other scientific articles have referred to that work–or citations.

Selected highly cited publications (>100 citations) utilizing one or more of the facilities at the BIDMC are listed below:

  1. Mice lacking melanin-concentrating hormone are hypophagic and lean Shimada et al Nature 1998
  2. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice Klaman et al MCB 2000
  3. βAR signaling required for diet-induced thermogenesis and obesity resistance Bachman et al Science 2002
  4. Melanin-concentrating Hormone Is a Critical Mediator of the Leptin-Deficient Phenotype Segal-Lieberman et al PNAS 2003
  5. Mice lacking ghrelin receptors resist the development of diet-induced obesity Zigman et al JCI 2005
  6. Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity Kershaw et al Diabetes 2005
  7. Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms Kokkotou et al AJP 2005
  8. TLR4 links innate immunity and fatty acid–induced insulin resistance Shi et al JCI 2006
  9. Neuronal PTP1B regulates body weight, adiposity and leptin action Bence et al Nature Medicine 2006
  10. A high-fat, ketogenic diet induces a unique metabolic state in mice Kennedy et al AJP 2007
  11. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice Bradley et al AJP 2008
  12. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle Martin et al JBC 2008
  13. Selective Inactivation of Socs3 in SF1 Neurons Improves Glucose Homeostasis without Affecting Body Weight Zhang et al Endocrinology 2008
  14. Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis Badman et al 2009 Endocrinology
  15. Leptin-dependent control of glucose balance and locomotor activity by POMC neurons Huo et al Cell Metabolism 2009
  16. Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis Preitner et al AJP 2009
  17. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice Krashes et al JCI 2011
  18. Transcriptional control of adipose lipid handling by IRF4 Eguchi et al Cell Metabolism 2011
  19. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons Vong et al Neuron 2011
  20. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis Fisher et al Genes and Development 2012
  21. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone Liu et al Neuron 2012
  22. IRF4 is a key thermogenic transcriptional partner of PGC-1α Kong et al Cell 2014
  23. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity Kraus et al Nature 2014
  24. An Erk/Cdk5 axis controls the diabetogenic actions of PPARγ Banks et al Nature 2015
  25. Central fibroblast growth factor 21 browns white fat via sympathetic action in male mice Douris et al Endocrinology 2015
  26. PTH/PTHrP receptor mediates cachexia in models of kidney failure and cancer Kir et al Cell Metabolism 2016
  27. Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity Kazak et al Cell Metabolism 2017

Funding: the Energy balance core is sponsored by the BIDMC Department of Medicine and the Harvard Digestive Disease Centers