Energy Balance Core

Welcome to the Energy Balance Core page!

The Energy Balance Core at BIDMC and Harvard Medical School is a facility designed for the measurement of energy intake, nutritional status, and energy expenditure in experimental mice. For more information about the specifics of what we do, please scroll through the drop-down above.

Thermal imaging (FLIR) of juvenile mice placed in a sterile 6-well culture dish.
Analysis of diet-induced obesity experiments: male C57Bl/6J mice, 11 weeks of low-fat diet (LFD) or high-fat diet (HFD). Corrigan et al eLife. Experiments were performed in the CLAMS at UC Davis.
Large-scale data analysis
EchoMRI 3-in-1 body composition analyzer
Germ-free mice can be examined using isolator cages (bottom). With this approach, we can examine the metabolic profile of germ-free mice or mice colonized with specific microbes.
Mice were housed at 30C, 23C, and 4C while monitoring both body weight and energy expenditure in the Promethion indirect calorimeter. Male C57Bl/6J mice from Jax ~10-14 weeks old. Data plotted in CalR
This data is from one female Swiss-Webster mouse injected intraperitonially with glucose at 2 grams per kilogram for a glucose tolerance test (GTT). The mouse was held in the Promethion over the course of several hours at 23C. Glucose level was continuously monitored and reading was recorded every minute.